The main ingredient in TA-65 is a herb called Astragalus membranaceus. The active ingredient from the herb is isolated to achieve greater bioavailability. The herb itself has a poor level of bioavailability. TA-65 was discovered in the 80s and is patented by Geron, an American company located in California.
What is the difference between telomere and telomerase [ELI5]
1.) The telomeres are at the end of the DNA. They protect against the loss of DNA information. Each time our DNA replicates, a little bit at the end of it can't get copied. So little by little, the DNA gets shorter. Telomeres are the solution to this issue. They're long strings of "nonsense. Think of it as the plastic caps at the ends of shoelaces.
2.) Telomerase is an enzyme that controls the telomeres. Cells that don't use or activate the enzyme telomerase age. Resulting in an aging body. If telomerase is switched on, the cell will continue to grow and divide, stopping the body from aging.
Studies on mice show promising effects
When cells divide, their telomeres shorten, a cell dies after a certain amount of divisions, which puts a cap on how long humans can live. 120 years seems to be around the maximum life span for humans at the moment.
The idea behind the TA-65 is that it both can protect and reverse the effect on aging. By safeguarding the chromosomes' tips, it seems likely that the body's aging can slow down. The finding gives a clue that by boosting telomerase activity, aging in humans can be reversed.
Can extending telomeres cause cancer?
Telomerase is often found in human cancers, indicating that it helps tumors grow faster, stopping these cells from dying. But you can also look at supporting telomerase as a method to prevent cells from aging and stopping them from becoming cancerous. It is possibly more to aging than shortened telomeres, but combining telomerase therapy with other treatments that target aging might be the best solution.
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